Sepsis Checklist

Sepsis, severe sepsis, and septic shock are associated with significant patient morbidity and mortality. The following checklist identifies the key interventions that should be implemented in any patient who demonstrates signs and/or symptoms of sepsis.

Sepsis is a documented or suspected infection with one or more of the following:

Sepsis Resuscitation Bundle
To be started immediately and completed within 3 hours.
  1. Measure STAT lactate level
  2. Obtain blood cultures prior to antibiotic administration (Do not delay antibiotics if unable to obtain cultures)
  3. Administer broad-spectrum antibiotics within one (1) hour
  4. If patient is hypotensive or lactate is > 4 mmol/L, give a minimum of 30 mL/kg of crystalloid

Septic Shock Bundle
To be started immediately and completed within 6 hours.
  1. Maintain mean arterial blood pressure (MAP) > 65 mmHg
  2. Begin vasopressors for hypotension that does not respond to initial fluid resuscitation
  3. If patient remains hypotensive despite volume resuscitation (septic shock) OR initial lactate > 4 mmol/L

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